Randall Lee, MD, PhD

Professor

CLINICAL INTERESTS: Dr. Lee is a Cardiologist and a Cardiac Electrophysiologist. He specializes in conduction disorders and arrhythmias such as atrial fibrillation, atrial flutter, ventricular tachycardia, sudden death and supraventricular tachycardia. He utilizes catheter ablation, LAA ligation for embolic stroke associated with atrial fibrillation and implantable devices (pacemakers and defibrillators) for the treatment of arrhythmias.

RESEARCH INTERESTS: Cardiac tissue engineering for myocardial repair/regeneration. Cardiac engineering for the development of devices and monitoring of arrhythmias and embolic stroke prevention. His research focuses on cellular and molecular aspects of cardiac arrhythmias and vascular regeneration. Dr. Lee uses genetic engineering techniques to investigate derangements during cardiac arrhythmias and myocardial infarctions and as possible therapeutic tools. Dr. Lee also is interested in cardiac development of the conduction system and the means to alter conduction, which then may be applied to diseased states.
Education
Postdoctoral Studies, 1992 - Biochemistry/Molecular Biology, Stanford University
Fellow, 1992 - Cardiology/Electrophysiology, University of California, San Francisco
Ph.D., 1984 - Pharmacology, University of California, Los Angeles
M.D., 1984 - School of Medicine, University of California, Los Angeles
Publications

  1. Ding C, Guo Z, Chen Z, Lee RJ, Rudin C, Hu X. SiamQuality: a ConvNet-based foundation model for photoplethysmography signals. Physiological measurement 2024. PMID: 39048103


  2. Shrestha UM, Chae HD, Fang Q, Lee RJ, Packiasamy J, Huynh L, Blecha J, Huynh TL, VanBrocklin HF, Levi J, Seo Y. A Feasibility Study of [18F]F-AraG Positron Emission Tomography (PET) for Cardiac Imaging-Myocardial Viability in Ischemia-Reperfusion Injury Model. Molecular imaging and biology 2024. PMID: 39060882


  3. Ding C, Guo Z, Rudin C, Xiao R, Shah A, Do DH, Lee RJ, Clifford G, Nahab FB, Hu X. Learning From Alarms: A Robust Learning Approach for Accurate Photoplethysmography-Based Atrial Fibrillation Detection using Eight Million Samples Labeled with Imprecise Arrhythmia Alarms. IEEE journal of biomedical and health informatics 2024. PMID: 38300786


  4. Shrestha U, Chae HD, Fang Q, Lee RJ, Packiasamy J, Huynh L, Blecha J, Huynh TL, VanBrocklin HF, Levi J, Seo Y. A feasibility study of [18F]F-AraG positron emission tomography (PET) for cardiac imaging - myocardial viability in ischemia-reperfusion injury model. Research square 2024. PMID: 38746162


  5. Lakkireddy DR, Wilber DJ, Mittal S, Tschopp D, Ellis CR, Rasekh A, Hounshell T, Evonich R, Chandhok S, Berger RD, Horton R, Hoskins MH, Calkins H, Yakubov SJ, Simons P, Saville BR, Lee RJ, aMAZE Investigators. Pulmonary Vein Isolation With or Without Left Atrial Appendage Ligation in Atrial Fibrillation: The aMAZE Randomized Clinical Trial. JAMA 2024. PMID: 38563835


  6. Wang B, Gao C, Lim S, Wang R, Zhu CJ, Onuma Y, Wang Y, Gao R, Serruys PWJC, Lee RJ, Tao L. Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study. Journal of cardiovascular translational research 2024. PMID: 38376702


  7. Wong CX, Buch EF, Beygui R, Lee RJ. Hybrid Endo-Epicardial Therapies for Advanced Atrial Fibrillation. Journal of clinical medicine 2024. PMID: 38337373


  8. Ciuffo L, Tung M, Dukes JW, Vittinghoff E, Moss JD, Lee RJ, Lee BK, Tseng ZH, Vedantham V, Olgin JE, Scheinman MM, Hsia H, Ramchandani VA, Gerstenfeld EP, Marcus GM. Acute alcohol exposure and electrocardiographic changes: Finding from the HOLIDAY trial. Journal of electrocardiology 2024. PMID: 38295539


  9. Batko J, Rusinek J, Slomka A, Litwinowicz R, Burysz M, Bartus M, Lakkireddy DR, Lee RJ, Natorska J, Zabczyk M, Kapelak B, Bartus K. Postoperative Coagulation Changes in Patients after Epicardial Left Atrial Appendage Occlusion Varies Based on the Left Atrial Appendage Size. Diseases (Basel, Switzerland) 2023. PMID: 38248359


  10. Mohindra P, Zhong JX, Fang Q, Cuylear DL, Huynh C, Qiu H, Gao D, Kharbikar BN, Huang X, Springer ML, Lee RJ, Desai TA. Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction. NPJ Regenerative medicine 2023. PMID: 37872196


  11. Murtha LA, Hardy SA, Mabotuwana NS, Bigland MJ, Bailey T, Raguram K, Liu S, Ngo DT, Sverdlov AL, Tomin T, Birner-Gruenberger R, Hume RD, Iismaa SE, Humphreys DT, Patrick R, Chong JJH, Lee RJ, Harvey RP, Graham RM, Rainer PP, Boyle AJ. Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction. Scientific Reports 2023. PMID: 37696945


  14. Lee AC, Voskoboinik A, Cheung CC, Yogi S, Tseng ZH, Moss JD, Dewland TA, Lee BK, Lee RJ, Hsia HH, Marcus GM, Vedantham V, Chieng D, Kistler PM, Dillon W, Vittinghoff E, Gerstenfeld EP. A Randomized Trial of High vs Standard Power Radiofrequency Ablation for Pulmonary Vein Isolation: SHORT-AF. JACC. Clinical electrophysiology 2023. PMID: 37495318


  15. de Asmundis C, Pannone L, Lakkireddy D, Beaver TM, Brodt CR, Lee RJ, Frazier K, Chierchia GB, La Meir M. Hybrid epicardial and endocardial sinus node-sparing ablation therapy for inappropriate sinus tachycardia: Rationale and design of the multicenter HEAL-IST IDE trial. Heart rhythm O2 2023. PMID: 37124558


  16. Howell SJ, Dukes JW, Vittinghoff E, Tang J, Moss JD, Lee RJ, Lee BK, Tseng ZH, Vedantham V, Olgin JE, Scheinman MM, Hsia H, Gerstenfeld EP, Marcus GM. Premature Atrial Contraction Location and Atrial Fibrillation Inducibility. Circulation. Arrhythmia and electrophysiology 2023. PMID: 36688298


  18. Ding C, Xiao R, Do D, Lee DS, Lee RJ, Kalantarian S, Hu X. Log-Spectral Matching GAN: PPG-based Atrial Fibrillation Detection can be Enhanced by GAN-based Data Augmentation with Integration of Spectral Loss. IEEE journal of biomedical and health informatics 2023. PMID: 37018611


  19. Dewland TA, Gerstenfeld EP, Moss JD, Lee AC, Vedantham V, Lee RJ, Tseng ZH, Hsia HH, Lee BK, Wall GC, Chang KR, Yang MH, Marcus GM. Randomized Comparison of a�Radiofrequency Wire Versus a�Radiofrequency Needle System for�Transseptal Puncture. JACC. Clinical electrophysiology 2022. PMID: 36752451


  20. Higuchi S, Ito H, Gerstenfeld EP, Lee AC, Lee BK, Marcus GM, Hsia HH, Moss JD, Lee RJ, Dewland TA, Vedantham V, Tseng ZH, Patel AR, Tanel RE, Badhwar N, Pellegrini CN, Kawamura M, Shoda M, Hwang C, Refaat MM, Scheinman MM. The Value of Programmed Ventricular Extrastimuli From the Right Ventricular�Basal Septum During Supraventricular Tachycardia. JACC. Clinical electrophysiology 2022. PMID: 36858688


  21. Ding C, Pereira T, Xiao R, Lee RJ, Hu X. Impact of Label Noise on the Learning Based Models for a Binary Classification of Physiological Signal. Sensors (Basel, Switzerland) 2022. PMID: 36236265


  22. de Asmundis C, Pannone L, Lakkireddy D, Beaver TM, Brodt CR, Lee RJ, Sorgente A, Gauthey A, Monaco C, Overeinder I, Bala G, Almorad A, Str?ker E, Sieira J, Brugada P, Chierchia GB, La Meir M, Olshansky B. Targeted Treatment of Inappropriate Sinoatrial Node Tachycardia Based on Electrophysiological and Structural Mechanisms. The American journal of cardiology 2022. PMID: 36127177


  23. Fang J, Li JJ, Zhong X, Zhou Y, Lee RJ, Cheng K, Li S. Engineering stem cell therapeutics for cardiac repair. Journal of molecular and cellular cardiology 2022. PMID: 35863282


  24. Lee RJ, Hanke T. The Strengths and Weaknesses of Left Atrial Appendage Ligation or Exclusion (LARIAT, AtriaClip, Surgical Suture). "Are Telehealth Visits Feasible for Vulnerable Patients?" 2022. PMID: 35361465


  25. Bartus K, Kanuri SH, Litwinowicz R, Ali Elbey M, Natorska J, Zabczyk M, Bartus M, Kapelak B, Gopinnathannair R, Garg J, Turagam MK, Malecki MT, Lee RJ, Lakkireddy D. Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis: LAA HOMEOSTASIS-2. "Are Telehealth Visits Feasible for Vulnerable Patients?" 2022. PMID: 35329819


  26. Marcus GM, Vittinghoff E, Whitman IR, Joyce S, Yang V, Nah G, Gerstenfeld EP, Moss JD, Lee RJ, Lee BK, Tseng ZH, Vedantham V, Olgin JE, Scheinman MM, Hsia H, Gladstone R, Fan S, Lee E, Fang C, Ogomori K, Fatch R, Hahn JA. Acute Consumption of Alcohol and Discrete Atrial Fibrillation Events. Annals of internal medicine 2021. PMID: 34461028


  27. Dewland TA, Yoruk A, Lee RJ. Epicardial Contrast Injection to Guide Left Atrial Appendage Closure. HeartRhythm case reports 2021. PMID: 34307032


  29. Marcus GM, Dukes JW, Vittinghoff E, Nah G, Badhwar N, Moss JD, Lee RJ, Lee BK, Tseng ZH, Walters TE, Vedantham V, Gladstone R, Fan S, Lee E, Fang C, Ogomori K, Hue T, Olgin JE, Scheinman MM, Hsia H, Ramchandani VA, Gerstenfeld EP. A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Alcohol to Assess Changes in Atrial Electrophysiology. JACC. Clinical electrophysiology 2021. PMID: 33516710


  30. Zhang O, Ding C, Pereira T, Xiao R, Gadhoumi K, Meisel K, Lee RJ, Chen Y, Hu X. Explainability Metrics of Deep Convolutional Networks for Photoplethysmography Quality Assessment. IEEE access : practical innovations, open solutions 2021. PMID: 33747683


  31. Bartus K, Litwinowicz R, Kapelak B, Filip G, Wierzbicki K, Lee RJ. Giant Left Atrium Associated with Massive Thrombus Formation 14 Years after Orthotopic Heart Transplantation. Brazilian journal of cardiovascular surgery 2020. PMID: 33306328


  32. Litwinowicz R, Burysz M, Mazur P, Kapelak B, Bartus M, Lakkireddy D, Lee RJ, Malec-Litwinowicz M, Bartus K. Endocardial versus epicardial left atrial appendage exclusion for stroke prevention in patients with atrial fibrillation: Midterm follow-up. Journal of cardiovascular electrophysiology 2020. PMID: 33146462


  33. Sanchez JM, Lee A, Bartus K, Lee RJ. Percutaneous epicardial approach for LAA ligation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2020. PMID: 33085054


  34. Perino AC, Kaiser DW, Lee RJ, Fan J, Askari M, Schmitt SK, Turakhia MP. Incidence and outcomes of patients with atrial fibrillation and major bleeding complications: from the TREAT-AF study. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2020. PMID: 32986177


  35. Ellis CR, Badhwar N, Tschopp D, Danter M, Jackson GG, Kerendi F, Walters T, Fang Q, Deuse T, Beygui R, Lee RJ. Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results. JACC. Clinical electrophysiology 2020. PMID: 33334437


  36. Tilz RR, Fink T, Bartus K, Wong T, Vogler J, Nentwich K, Panniker S, Fang Q, Piorkowski C, Liosis S, Gaspar T, Sawan N, Metzner A, Nietlispach F, Maisano F, Lee RJ, Foran JP, Ouyang F, Sievert H, Deneke T, Kuck KH. A collective European experience with left atrial appendage suture ligation using the LARIAT+ device. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2020. PMID: 32044994


  37. Pereira T, Tran N, Gadhoumi K, Pelter MM, Do DH, Lee RJ, Colorado R, Meisel K, Hu X. Photoplethysmography based atrial fibrillation detection: a review. NPJ digital medicine 2020. PMID: 31934647


  38. Voskoboinik A, Lee RJ. Anatomic Considerations for Epicardial and Endocardial Left Atrial Appendage Closure. Cardiac electrophysiology clinics 2019. PMID: 32067646


  39. Henry JJD, Delrosario L, Fang J, Wong SY, Fang Q, Sievers R, Kotha S, Wang A, Farmer D, Janaswamy P, Lee RJ, Li S. Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair. Advanced healthcare materials 2019. PMID: 31778043


  40. Bartus K, Litwinowicz R, Natorska J, Zabczyk M, Undas A, Kapelak B, Lakkireddy D, Lee RJ. Coagulation factors and fibrinolytic activity in the left atrial appendage and other heart chambers in patients with atrial fibrillation: is there a local intracardiac prothrombotic state? (HEART-CLOT study). International journal of cardiology 2019. PMID: 31787387


  41. Litwinowicz R, Bartus M, Kapelak B, Suwalski P, Lakkireddy D, Lee RJ, Bartus K. Reduction in risk of stroke and bleeding after left atrial appendage closure with LARIAT device in patients with increased risk of stroke and bleeding: Long term results. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2019. PMID: 30884101


  42. Hardy SA, Mabotuwana NS, Murtha LA, Coulter B, Sanchez-Bezanilla S, Al-Omary MS, Senanayake T, Loering S, Starkey M, Lee RJ, Rainer PP, Hansbro PM, Boyle AJ. Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction. PloS one 2019. PMID: 30789914


  43. Tsai CC, Hong YJ, Lee RJ, Cheng NC, Yu J. Enhancement of human adipose-derived stem cell spheroid differentiation in an in situ enzyme-crosslinked gelatin hydrogel. Journal of materials chemistry. B 2019. PMID: 32254774


  44. Litwinowicz R, Bartus M, Burysz M, Brzezinski M, Suwalski P, Kapelak B, Vuddanda V, Lakkireddy D, Lee RJ, Trabka R, Bartus K. Long term outcomes after left atrial appendage closure with the LARIAT device-Stroke risk reduction over five years follow-up. PloS one 2018. PMID: 30566961


  45. Bartus K, Myc J, Bartus M, Lee RJ, Litwinowicz R, Dziewierz A, Kapelak B. Rapid left atrial appendage thrombus formation before suture ligation with LARIAT. Postepy w kardiologii interwencyjnej = Advances in interventional cardiology 2018. PMID: 30603036


  46. Margulis K, Zhou Z, Fang Q, Sievers RE, Lee RJ, Zare RN. Combining Desorption Electrospray Ionization Mass Spectrometry Imaging and Machine Learning for Molecular Recognition of Myocardial Infarction. Analytical chemistry 2018. PMID: 30188683


  47. Chow DHF, Wong YH, Park JW, Lam YY, De Potter T, Rodés-Cabau J, Asmarats L, Sandri M, Sideris E, McCaw T, Lee RJ, Sievert H, Søndergaard L, De Backer O. An overview of current and emerging devices for percutaneous left atrial appendage closure. Trends in cardiovascular medicine 2018. PMID: 30205924


  49. Ito H, Badhwar N, Patel AR, Hoffmayer KS, Moss JD, Pellegrini CN, Vedantham V, Tseng ZH, Tanel RE, Hsia HH, Lee RJ, Marcus GM, Gerstenfeld EP, Scheinman MM. Use of Programmed Ventricular Extrastimulus During Supraventricular Tachycardia to Differentiate Atrioventricular Nodal Re-Entrant Tachycardia From Atrioventricular Re-Entrant Tachycardia. 2018. PMID: 30025686


  50. Le LV, Mohindra P, Fang Q, Sievers RE, Mkrtschjan MA, Solis C, Safranek CW, Russell B, Lee RJ, Desai TA. Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction. Biomaterials 2018. PMID: 29631164


  51. Sanchez JM, Al-Dosari G, Chu S, Beygui R, Deuse T, Badhwar N, Lee RJ. Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation. Expert review of cardiovascular therapy 2018. PMID: 29327638


  52. Govea A, Lee RJ. Pericardial Delivery of Biological Agents: The Next Frontier? JACC. Basic to translational science 2017. PMID: 30062174


  53. Redfors B, Gray WA, Lee RJ, Ellenbogen KA, Bonafede M, Ben-Yehuda O. Patients With Atrial Fibrillation Who Are Not on Anticoagulant Treatment Due to Increased Bleeding Risk Are Common and Have a High Risk of Stroke. JACC. Clinical electrophysiology 2017. PMID: 29759666


  54. Szilágyi J, Marcus GM, Badhwar N, Lee BK, Lee RJ, Vedantham V, Tseng ZH, Walters T, Scheinman M, Olgin J, Gerstenfeld EP. Atrial fibrillation patients with isolated pulmonary veins: Is sinus rhythm achievable? Journal of cardiovascular electrophysiology 2017. PMID: 28429499


  55. Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling. American journal of cardiovascular disease 2017. PMID: 28695053


  56. Nguyen KT, Gladstone RA, Dukes JW, Nazer B, Vittinghoff E, Badhwar N, Vedantham V, Gerstenfeld EP, Lee BK, Lee RJ, Tseng ZH, Olgin JE, Scheinman MM, Marcus GM. The QT Interval as a Noninvasive Marker of Atrial Refractoriness. Pacing and clinical electrophysiology : PACE 2016. PMID: 27753113


  57. Badhwar N, Mittal S, Rasekh A, Vasaiwala S, Musat D, S Naeini P, Fang Q, Nentwich K, Deneke T, Chang J, Lakkireddy D, Wilber D, Lee RJ. Conversion of persistent atrial fibrillation to sinus rhythm after LAA ligation with the LARIAT device. International journal of cardiology 2016. PMID: 27718444


  58. Janaswamy P, Walters TE, Nazer B, Lee RJ. Current Treatment Strategies for Heart Failure: Role of Device Therapy and LV Reconstruction. Current treatment options in cardiovascular medicine 2016. PMID: 27488313


  60. Bartus K, Gafoor S, Tschopp D, Foran JP, Tilz R, Wong T, Lakkireddy D, Sievert H, Lee RJ. Left atrial appendage ligation with the next generation LARIAT(+) suture delivery device: Early clinical experience. International journal of cardiology 2016. PMID: 27128539


  61. Lakkireddy D, Afzal MR, Lee RJ, Nagaraj H, Tschopp D, Gidney B, Ellis C, Altman E, Lee B, Kar S, Bhadwar N, Sanchez M, Gadiyaram V, Evonich R, Rasekh A, Cheng J, Cuoco F, Chandhok S, Gunda S, Reddy M, Atkins D, Bommana S, Cuculich P, Gibson D, Nath J, Ferrell R, Matthew E, Wilber D. Short and long-term outcomes of percutaneous left atrial appendage suture ligation: Results from a US multicenter evaluation. Heart rhythm 2016. PMID: 26872554


  62. Gunda S, Reddy M, Nath J, Nagaraj H, Atoui M, Rasekh A, Ellis CR, Badhwar N, Lee RJ, DI Biase L, Mansour M, Ruskin JN, Natale A, Earnest M, Lakkireddy DR. Impact of Periprocedural Colchicine on Postprocedural Management in Patients Undergoing a Left Atrial Appendage Ligation Using LARIAT. Journal of cardiovascular electrophysiology 2015. PMID: 26515657


  63. Hall PS, Nazer B, Lee RJ. Reversible High-Grade Atrioventricular Block Associated With Cocaine Use. JAMA internal medicine 2015. PMID: 26437019


  64. Mann DL, Lee RJ, Coats AJ, Neagoe G, Dragomir D, Pusineri E, Piredda M, Bettari L, Kirwan BA, Dowling R, Volterrani M, Solomon SD, Sabbah HN, Hinson A, Anker SD. One-year follow-up results from AUGMENT-HF: a multicentre randomized controlled clinical trial of the efficacy of left ventricular augmentation with Algisyl in the treatment of heart failure. European journal of heart failure 2015. PMID: 26555602


  65. Sievert H, Rasekh A, Bartus K, Morelli RL, Fang Q, Kuropka J, Le D, Gafoor S, Heuer L, Safavi-Naeini P, Hue TF, Marcus GM, Badhwar N, Massumi A, Lee RJ. Left Atrial Appendage Ligation in Nonvalvular Atrial Fibrillation Patients at High Risk for Embolic Events With Ineligibility for Oral Anticoagulation: Initial Report of Clinical Outcomes. JACC. Clinical electrophysiology 2015. PMID: 29759399


  66. Lee RJ, Lakkireddy D, Mittal S, Ellis C, Connor JT, Saville BR, Wilber D. Percutaneous alternative to the Maze procedure for the treatment of persistent or long-standing persistent atrial fibrillation (aMAZE trial): Rationale and design. American heart journal 2015. PMID: 26678640


  67. Ito H, Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Gerstenfeld EP, Scheinman MM. The Effect of Direct Current Stimulation versus T-Wave Shock on Defibrillation Threshold Testing. Pacing and clinical electrophysiology : PACE 2015. PMID: 26137999


  68. Lee RJ, Hinson A, Bauernschmitt R, Matschke K, Fang Q, Mann DL, Dowling R, Schiller N, Sabbah HN. The feasibility and safety of Algisyl-LVR™ as a method of left ventricular augmentation in patients with dilated cardiomyopathy: initial first in man clinical results. International journal of cardiology 2015. PMID: 26173169


  69. Anker SD, Coats AJ, Cristian G, Dragomir D, Pusineri E, Piredda M, Bettari L, Dowling R, Volterrani M, Kirwan BA, Filippatos G, Mas JL, Danchin N, Solomon SD, Lee RJ, Ahmann F, Hinson A, Sabbah HN, Mann DL. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial). European heart journal 2015. PMID: 26082085


  70. Le D, Morelli R, Badhwar N, Lee RJ. Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. Expert review of cardiovascular therapy 2015. PMID: 26070218


  71. Kawamura M, Scheinman MM, Lee RJ, Badhwar N. Left atrial appendage ligation in patients with atrial fibrillation leads to a decrease in atrial dispersion. Journal of the American Heart Association 2015. PMID: 25977469


  72. Badhwar N, Lakkireddy D, Kawamura M, Han FT, Iyer SK, Moyers BS, Dewland TA, Woods C, Ferrell R, Nath J, Earnest M, Lee RJ. Sequential Percutaneous LAA Ligation and Pulmonary Vein Isolation in Patients with Persistent AF: Initial Results of a Feasibility Study. Journal of cardiovascular electrophysiology 2015. PMID: 25772569


  73. Yu J, Wu YK, Gu Y, Fang Q, Sievers R, Ding CH, Olgin JE, Lee RJ. Immuno-modification of enhancing stem cells targeting for myocardial repair. Journal of cellular and molecular medicine 2015. PMID: 25904069


  74. Nguyen J, Sievers R, Motion JP, Kivimäe S, Fang Q, Lee RJ. Delivery of lipid micelles into infarcted myocardium using a lipid-linked matrix metalloproteinase targeting peptide. Molecular pharmaceutics 2015. PMID: 25642730


  76. Afzal MR, Kanmanthareddy A, Earnest M, Reddy M, Atkins D, Bommana S, Bartus K, Rasekh A, Han F, Badhwar N, Cheng J, Dibiase L, Ellis CR, Dawn B, Natale A, Lee RJ, Lakkireddy D. Impact of left atrial appendage exclusion using an epicardial ligation system (LARIAT) on atrial fibrillation burden in patients with cardiac implantable electronic devices. Heart rhythm 2014. PMID: 25281005


  77. Bartus K, Morelli RL, Szczepanski W, Kapelak B, Sadowski J, Lee RJ. Anatomic analysis of the left atrial appendage after closure with the LARIAT device. Circulation. Arrhythmia and electrophysiology 2014. PMID: 25140024


  78. Pinney JR, Du KT, Ayala P, Fang Q, Sievers RE, Chew P, Delrosario L, Lee RJ, Desai TA. Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction. Biomaterials 2014. PMID: 25047625


  79. Lee RJ. Evolution of stroke prevention in nonvalvular atrial fibrillation patients. Journal of the American College of Cardiology 2014. PMID: 24998122


  80. Singh DK, Viswanathan MN, Tanel RE, Lee RJ, Lee BK, Marcus GM, Olgin JE, Han F, Vedantham V, Tseng ZH, Pellegrini C, Kawamura M, Gerstenfeld EP, Badhwar N, Scheinman M. His overdrive pacing during supraventricular tachycardia: a novel maneuver for distinguishing atrioventricular nodal reentrant tachycardia from atrioventricular reciprocating tachycardia. Volume 11 of Issue 8. 2014. PMID: 24793458


  81. Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Olgin JE, Gerstenfeld EP, Scheinman MM. Coupling interval dispersion and body mass index are independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy. Journal of cardiovascular electrophysiology 2014. PMID: 24612052


  82. Stepanyan G, Badhwar N, Lee RJ, Marcus GM, Lee BK, Tseng ZH, Vedantham V, Olgin J, Scheinman M, Gerstenfeld EP. Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2014. PMID: 24643666


  83. Koneru JN, Badhwar N, Ellenbogen KA, Lee RJ. LAA ligation using the LARIAT suture delivery device: tips and tricks for a successful procedure. Heart rhythm 2014. PMID: 24462524


  84. Han FT, Bartus K, Lakkireddy D, Rojas F, Bednarek J, Kapelak B, Bartus M, Sadowski J, Badhwar N, Earnest M, Valderrabano M, Lee RJ. The effects of LAA ligation on LAA electrical activity. Heart rhythm 2014. PMID: 24444443


  85. Boyle AJ, Hwang J, Ye J, Shih H, Jun K, Zhang Y, Fang Q, Sievers R, Yeghiazarians Y, Lee RJ. The effects of aging on apoptosis following myocardial infarction. Cardiovascular therapeutics 2013. PMID: 24279384


  86. Ye J, Hom DS, Hwang J, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging Impairs the Proliferative Capacity of Cardiospheres, Cardiac Progenitor Cells and Cardiac Fibroblasts: Implications for Cell Therapy. Journal of clinical medicine 2013. PMID: 26237065


  87. Hsu JC, Badhwar N, Gerstenfeld EP, Lee RJ, Mandyam MC, Dewland TA, Imburgia KE, Hoffmayer KS, Vedantham V, Lee BK, Tseng ZH, Scheinman MM, Olgin JE, Marcus GM. Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study). Journal of the American Heart Association 2013. PMID: 24045120


  88. Hashem SI, Lam ML, Mihardja SS, White SM, Lee RJ, Claycomb WC. Shox2 regulates the pacemaker gene program in embryoid bodies. Stem cells and development 2013. PMID: 23767866


  89. Mihardja SS, Gonzales JA, Gao D, Sievers RE, Fang Q, Stillson CA, Yu J, Peng M, Lee RJ. The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model. Biomaterials 2013. PMID: 23895998


  90. Sabbah HN, Wang M, Gupta RC, Rastogi S, Ilsar I, Sabbah MS, Kohli S, Helgerson S, Lee RJ. Augmentation of left ventricular wall thickness with alginate hydrogel implants improves left ventricular function and prevents progressive remodeling in dogs with chronic heart failure. JACC. Heart failure 2013. PMID: 23998003


  91. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PloS one 2013. PMID: 23630585


  92. Lee LC, Wall ST, Klepach D, Ge L, Zhang Z, Lee RJ, Hinson A, Gorman JH, Gorman RC, Guccione JM. Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart. International journal of cardiology 2013. PMID: 23394895


  93. Bartus K, Han FT, Bednarek J, Myc J, Kapelak B, Sadowski J, Lelakowski J, Bartus S, Yakubov SJ, Lee RJ. Percutaneous left atrial appendage suture ligation using the LARIAT device in patients with atrial fibrillation: initial clinical experience. Journal of the American College of Cardiology 2012. PMID: 23062528


  94. Mihardja SS, Lee RJ. Using extracellular matrix-derived peptides to alter the microenvironment for myocardial repair. Current vascular pharmacology 2012. PMID: 22239636


  95. Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Gerstenfeld EP, Olgin JE, Marcus GM. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. The American journal of cardiology 2012. PMID: 22521307


  96. Lee RJ, Hinson A, Helgerson S, Bauernschmitt R, Sabbah HN. Polymer-based restoration of left ventricular mechanics. Cell transplantation 2012. PMID: 22469060


  97. Hsu JC, Friday J, Lee BK, Azadani PN, Lee RJ, Badhwar N, Tseng ZH, Olgin JE, Marcus GM. Predictors of axillary vein location for vascular access during pacemaker and defibrillator lead implantation. Pacing and clinical electrophysiology : PACE 2011. PMID: 21819433


  98. Hoffmayer KS, Yang Y, Joseph S, McCabe JM, Bhave P, Hsu J, Ng RK, Lee BK, Badhwar N, Lee RJ, Tseng ZH, Olgin JE, Narayan SM, Marcus GM, Scheinman MM. Predictors of unusual ECG characteristics in cavotricuspid isthmus-dependent atrial flutter ablation. Pacing and clinical electrophysiology : PACE 2011. PMID: 21605144


  99. Iwai S, Badhwar N, Markowitz SM, Stambler BS, Keung E, Lee RJ, Chung JH, Olgin JE, Scheinman MM, Lerman BB. Electrophysiologic properties of para-Hisian atrial tachycardia. Heart rhythm 2011. PMID: 21397044


  100. Mihardja SS, Yu J, Lee RJ. Extracellular matrix-derived peptides and myocardial repair. Cell adhesion & migration 2011. PMID: 21048428


  101. Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS. An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors. PloS one 2011. PMID: 21245908


  102. Shih H, Lee B, Lee RJ, Boyle AJ. The aging heart and post-infarction left ventricular remodeling. Journal of the American College of Cardiology 2011. PMID: 21185495


  103. Huang NF, Kurpinski K, Fang Q, Lee RJ, Li S. Proteomic identification of biomarkers of vascular injury. American journal of translational research 2010. PMID: 21416056


  104. Bartus K, Bednarek J, Myc J, Kapelak B, Sadowski J, Lelakowski J, Yakubov SJ, Lee RJ. Feasibility of closed-chest ligation of the left atrial appendage in humans. Heart rhythm 2010. PMID: 21050893


  105. Yang Y, Varma N, Badhwar N, Tanel RE, Sundara S, Lee RJ, Lee BK, Tseng ZH, Marcus GM, Kim AM, Olgin JE, Scheinman MM. Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentry. Journal of cardiovascular electrophysiology 2010. PMID: 20455984


  106. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials 2010. PMID: 20566215


  107. Huang NF, Chu J, Lee RJ, Li S. Biophysical and chemical effects of fibrin on mesenchymal stromal cell gene expression. Acta biomaterialia 2010. PMID: 20678460


  109. Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ. Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PloS one 2010. PMID: 20442783


  110. Ding C, Gepstein L, Nguyen DT, Wilson E, Hulley G, Beaser A, Lee RJ, Olgin J. High-resolution optical mapping of ventricular tachycardia in rats with chronic myocardial infarction. Pacing and clinical electrophysiology : PACE 2010. PMID: 20180914


  111. Huang NF, Lee RJ, Li S. Engineering of aligned skeletal muscle by micropatterning. American journal of translational research 2010. PMID: 20182581


  112. Lee RJ. Stem cells for myocardial repair and regeneration: where are we today? Methods in molecular biology (Clifton, N.J.) 2010. PMID: 20680809


  113. Marcus GM, Smith LM, Ordovas K, Scheinman MM, Kim AM, Badhwar N, Lee RJ, Tseng ZH, Lee BK, Olgin JE. Intracardiac and extracardiac markers of inflammation during atrial fibrillation. Heart rhythm 2009. PMID: 20022819


  114. Hsu JC, Tanel RE, Lee BK, Scheinman MM, Badhwar N, Lee RJ, Tseng ZH, Olgin JE, Marcus GM. Differences in accessory pathway location by sex and race. Heart rhythm 2009. PMID: 19914144


  115. Sakhuja R, Smith LM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE, Marcus GM. Test characteristics of neck fullness and witnessed neck pulsations in the diagnosis of typical AV nodal reentrant tachycardia. Clinical cardiology 2009. PMID: 19479968


  116. Huang NF, Lam A, Fang Q, Sievers RE, Li S, Lee RJ. Bone marrow-derived mesenchymal stem cells in fibrin augment angiogenesis in the chronically infarcted myocardium. Regenerative medicine 2009. PMID: 19580402


  117. Cao F, Xie X, Gollan T, Zhao L, Narsinh K, Lee RJ, Wu JC. Comparison of gene-transfer efficiency in human embryonic stem cells. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2009. PMID: 19551446


  118. Kim AM, Badhwar N, Lee RJ. Remote navigation guided ablation of incessant atrial tachycardia in a patient with restricted venous access. Journal of cardiovascular electrophysiology 2009. PMID: 19207779


  119. Yu J, Christman KL, Chin E, Sievers RE, Saeed M, Lee RJ. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. The Journal of thoracic and cardiovascular surgery 2009. PMID: 19154923


  120. Yu J, Gu Y, Du KT, Mihardja S, Sievers RE, Lee RJ. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials 2008. PMID: 19010528


  121. Kim AM, Turakhia M, Lu J, Badhwar N, Lee BK, Lee RJ, Marcus GM, Tseng ZH, Scheinman M, Olgin JE. Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time. Pacing and clinical electrophysiology : PACE 2008. PMID: 18950296


  122. McCabe JM, Smith LM, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE, Marcus GM. Protracted CRP elevation after atrial fibrillation ablation. Pacing and clinical electrophysiology : PACE 2008. PMID: 18834466


  123. Mihardja SS, Sievers RE, Lee RJ. The effect of polypyrrole on arteriogenesis in an acute rat infarct model. Biomaterials 2008. PMID: 18678406


  124. Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. Journal of cellular physiology 2008. PMID: 17960557


  125. Marcus GM, Smith LM, Whiteman D, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE. Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory period. Pacing and clinical electrophysiology : PACE 2008. PMID: 18307620


  126. Zhao TC, Tseng A, Yano N, Tseng Y, Davol PA, Lee RJ, Lum LG, Padbury JF. Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction. Journal of applied physiology (Bethesda, Md. : 1985) 2008. PMID: 18292296


  127. Marcus GM, Smith LM, Vittinghoff E, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE. A first-degree family history in lone atrial fibrillation patients. Heart rhythm 2008. PMID: 18468961


  128. Marcus GM, Smith LM, Glidden DV, Wilson E, McCabe JM, Whiteman D, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE. Markers of inflammation before and after curative ablation of atrial flutter. Heart rhythm 2007. PMID: 18242542


  129. Gu Y, Yu J, Lum LG, Lee RJ. Tissue engineering and stem cell therapy for myocardial repair. Frontiers in bioscience : a journal and virtual library 2007. PMID: 17569637


  131. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. Journal of applied physiology (Bethesda, Md. : 1985) 2007. PMID: 17347379


  132. Lee RJ, Fang Q, Davol PA, Gu Y, Sievers RE, Grabert RC, Gall JM, Tsang E, Yee MS, Fok H, Huang NF, Padbury JF, Larrick JW, Lum LG. Antibody targeting of stem cells to infarcted myocardium. Stem cells (Dayton, Ohio) 2006. PMID: 17138964


  133. Marcus GM, Ren X, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Foster E, Olgin JE. Repeat transseptal catheterization after ablation for atrial fibrillation. Journal of cardiovascular electrophysiology 2006. PMID: 17081207


  134. Marcus GM, Yang Y, Varosy PD, Ordovas K, Tseng ZH, Badhwar N, Lee BK, Lee RJ, Scheinman MM, Olgin JE. Regional left atrial voltage in patients with atrial fibrillation. Heart rhythm 2006. PMID: 17275746


  135. Nakai T, Chandy J, Nakai K, Bellows WH, Flachsbart K, Lee RJ, Leung JM. Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery. Cardiology 2006. PMID: 17008797


  136. Christman KL, Lee RJ. Biomaterials for the treatment of myocardial infarction. Journal of the American College of Cardiology 2006. PMID: 16949479


  137. Saeed M, Martin AJ, Lee RJ, Weber O, Revel D, Saloner D, Higgins CB. MR guidance of targeted injections into border and core of scarred myocardium in pigs. Radiology 2006. PMID: 16801371


  138. Huang NF, Patel S, Thakar RG, Wu J, Hsiao BS, Chu B, Lee RJ, Li S. Myotube assembly on nanofibrous and micropatterned polymers. Nano letters 2006. PMID: 16522058


  139. Huang NF, Sievers RE, Park JS, Fang Q, Li S, Lee RJ. A rodent model of myocardial infarction for testing the efficacy of cells and polymers for myocardial reconstruction. Nature protocols 2006. PMID: 17406452


  140. Lum LG, Davol PA, Lee RJ. The new face of bispecific antibodies: targeting cancer and much more. Experimental hematology 2006. PMID: 16413384


  141. Saeed M, Lee RJ, Weber O, Do L, Martin A, Ursell P, Saloner D, Higgins CB. Scarred myocardium imposes additional burden on remote viable myocardium despite a reduction in the extent of area with late contrast MR enhancement. European radiology 2005. PMID: 16362420


  142. Huang NF, Yu J, Sievers R, Li S, Lee RJ. Injectable biopolymers enhance angiogenesis after myocardial infarction. Tissue engineering 2005. PMID: 16411832


  143. Badhwar N, Kalman JM, Sparks PB, Kistler PM, Attari M, Berger M, Lee RJ, Sra J, Scheinman MM. Atrial tachycardia arising from the coronary sinus musculature: electrophysiological characteristics and long-term outcomes of radiofrequency ablation. Journal of the American College of Cardiology 2005. PMID: 16286181


  144. Lum LG, Padbury JF, Davol PA, Lee RJ. Virtual reality of stem cell transplantation to repair injured myocardium. Journal of cellular biochemistry 2005. PMID: 15962306


  145. Christman KL, Fang Q, Kim AJ, Sievers RE, Fok HH, Candia AF, Colley KJ, Herradon G, Ezquerra L, Deuel TF, Lee RJ. Pleiotrophin induces formation of functional neovasculature in vivo. Biochemical and biophysical research communications 2005. PMID: 15949466


  146. Cheng J, Yang Y, Ursell PC, Lee RJ, Dorostkar PC, Boahene KA, Scheinman MM. Protected circumferential conduction in the posterior atrioventricular vestibule of the left atrium: electrophysiologic and anatomic correlates. Pacing and clinical electrophysiology : PACE 2005. PMID: 16008806


  147. Christman KL, Fang Q, Yee MS, Johnson KR, Sievers RE, Lee RJ. Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymer. Biomaterials 2005. PMID: 15451633


  148. Christman KL, Vardanian AJ, Fang Q, Sievers RE, Fok HH, Lee RJ. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. Journal of the American College of Cardiology 2004. PMID: 15358036


  149. Christman KL, Fok HH, Sievers RE, Fang Q, Lee RJ. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue engineering 2004. PMID: 15165457


  150. Matsushita T, Badhwar N, Collins KK, Van Hare GF, Barbato G, Lee BK, Lee RJ, Scheinman MM. Usefulness of a ventricular extrastimulus from the summit of the ventricular septum in diagnosis of septal accessory pathway in patients with supraventricular tachycardia. The American journal of cardiology 2004. PMID: 14996601


  151. Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung JM. Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery. Anesthesia and analgesia 2004. PMID: 14742359


  152. Lum LG, Fok H, Sievers R, Abedi M, Quesenberry PJ, Lee RJ. Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium. Blood cells, molecules & diseases 2004. PMID: 14757418


  153. Huang NF, Thakar RG, Wong M, Kim D, Lee RJ, Li S. Tissue engineering of muscle on micropatterned polymer films. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2004. PMID: 17271429


  154. Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW. Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice. Journal of the American College of Cardiology 2003. PMID: 12906991


  155. Bochoeyer A, Yang Y, Cheng J, Lee RJ, Keung EC, Marrouche NF, Natale A, Scheinman MM. Surface electrocardiographic characteristics of right and left atrial flutter. Circulation 2003. PMID: 12835225


  156. Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. Journal of the renin-angiotensin-aldosterone system : JRAAS 2003. PMID: 12692751


  158. Nakai T, Lesh MD, Gerstenfeld EP, Virmani R, Jones R, Lee RJ. Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine model. Circulation 2002. PMID: 11994258


  159. Zhu BQ, Sievers RE, Browne AE, Hillman RT, Chair K, Lee RJ, Chatterjee K, Glantz SA, Parmley WW. The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke. Volume 3 of Issue 1. 2002. PMID: 11984749


  160. Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung JM. The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery. American heart journal 2002. PMID: 11773931