Noa Simchoni, MD, PhD

Clinical Instructor

Publications

  1. N. Simchoni, S. Agezew, A. Shum. Functional Validation of Variants of Unknown Significance in COPA Syndrome. American journal of respiratory and critical care medicine 2025. PMID:


  2. Simchoni N, Koide S, Likhite M, Kuchitsu Y, Kadirvel S, Law CS, Elicker BM, Kurra S, Wong MM, Yuan B, Grossi A, Laxer RM, Volpi S, Dissanayake D, Taguchi T, Beck DB, Vogel TP, Shum AK. The common HAQ STING allele prevents clinical penetrance of COPA syndrome. The Journal of experimental medicine 2025. PMID: 40014299


  3. Deng Z, Law CS, Kurra S, Simchoni N, Shum AK. Activated STING in the thymus alters T cell development and selection leading to autoimmunity. bioRxiv : the preprint server for biology 2024. PMID: 38464209


  4. Anna Pavlova, Sasthi C. Mandal, Noa Simchoni, Christopher S. Law, Atanu Acharya, Anthony K. Shum, James C. Gumbart. Pathogenic COPA mutations decrease binding of dilysine motifs through allosteric effects. Biophysical Journal 2024. PMID:


  5. Simchoni N, Vogel TP, Shum AK. COPA Syndrome from Diagnosis to Treatment: A Clinician's Guide. Rheumatic diseases clinics of North America 2023. PMID: 37821196


  6. Berger AC, Simchoni N, Auerbach A, Brode WM, Kuperman E, Raffel K, Kubey A, HOMERuN COVID-19 Collaborative Group. Implementation of Clinical Practice Guidelines for Hospitalized Patients With COVID-19 in Academic Medical Centers. "Are Telehealth Visits Feasible for Vulnerable Patients?" 2022. PMID: 35377428


  7. Noa Simchoni, Lurit Bepo, Kaitlyn Tracy, Travis Zack. AN UNUSUAL CASE OF INNUMERABLE LUNG NODULES. 2019. PMID:


  8. Ruane D, Chorny A, Lee H, Faith J, Pandey G, Shan M, Simchoni N, Rahman A, Garg A, Weinstein EG, Oropallo M, Gaylord M, Ungaro R, Cunningham-Rundles C, Alexandropoulos K, Mucida D, Merad M, Cerutti A, Mehandru S. Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses. Volume 213 of Issue 1. 2015. PMID: 26712806


  9. Cols M, Rahman A, Maglione PJ, Garcia-Carmona Y, Simchoni N, Ko HM, Radigan L, Cerutti A, Blankenship D, Pascual V, Cunningham-Rundles C. Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency. Volume 137 of Issue 4. 2015. PMID: 26542033


  10. Ramesh M, Simchoni N, Hamm D, Cunningham-Rundles C. High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia. Volume 161 of Issue 2. 2015. PMID: 26360253


  11. Roskin KM, Simchoni N, Liu Y, Lee JY, Seo K, Hoh RA, Pham T, Park JH, Furman D, Dekker CL, Davis MM, James JA, Nadeau KC, Cunningham-Rundles C, Boyd SD. IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Volume 7 of Issue 302. Science translational medicine 2015. PMID: 26311730


  12. Maglione PJ, Simchoni N, Cunningham-Rundles C. Toll-like receptor signaling in primary immune deficiencies. Volume 1356. 2015. PMID: 25930993


  13. Saiman Y, Sugiyama T, Simchoni N, Spirli C, Bansal MB. Biliary Epithelial Cells Are Not the Predominant Source of Hepatic CXCL12. Volume 185 of Issue 7. 2015. PMID: 25934614


  14. Simchoni N, Cunningham-Rundles C. TLR7- and TLR9-responsive human B cells share phenotypic and genetic characteristics. Volume 194 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 25740945


  15. Ramesh M, Hamm D, Simchoni N, Cunningham-Rundles C. Clonal and constricted T cell repertoire in Common Variable Immune Deficiency. Volume 178. 2015. PMID: 25596453


  16. Maglione PJ, Simchoni N, Black S, Radigan L, Overbey JR, Bagiella E, Bussel JB, Bossuyt X, Casanova JL, Meyts I, Cerutti A, Picard C, Cunningham-Rundles C. IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens. Volume 124 of Issue 24. Blood 2014. PMID: 25320238


  17. Noa Simchoni, Charlotte Cunningam-Rundles. Selectivity of Toll-like receptor stimulation in human B cells (HUM8P.350). The Journal of Immunology 2014. PMID:


  18. Noa Simchoni, Krishna Roskin, Scott Boyd, Charlotte Cunningam-Rundles. Deep sequencing of the IgH locus in CVID reveals global alterations in central and peripheral B cell development (P3329). The Journal of Immunology 2013. PMID: