John Kane, MD, PhD

Professor

Dr. John Kane is an endocrinologist and director of the UCSF Lipid Clinic. He is also an associate director of the UCSF Cardiovascular Research Institute.

Kane's research on lipoprotein metabolism, the management of lipoprotein disorders, and the genetic basis of heart disease and stroke is known worldwide through his publications in refereed journals and book chapters.

Kane earned his medical degree at the University of Oregon School of Medicine. He completed a residency in internal medicine at Stanford University and UCSF, followed by a fellowship in endocrinology at UCSF.

Kane was an Established Investigator and fellow of the American Heart Association. He received an outstanding achievement award from the International Atherosclerosis Society for his work in the genetics of lipoprotein metabolism and atherosclerosis. He is a diplomate of the American Board of Clinical Lipidology.
Education
Ph.D., 1971 - Graduate Division (Biochemistry), University of California, San Francisco
Publications

  1. Saharan SS, Nagar P, Creasy KT, Stock EO, Feng J, Malloy MJ, Kane JP. Logistic Regression and Statistical Regularization Techniques for Risk Classification of Coronary Artery Disease using Cytokines transported by high density lipoproteins. Proceedings. International Conference on Computational Science and Computational Intelligence 2024. PMID: 39484231


  2. Saharan SS, Nagar P, Creasy KT, Stock EO, Feng J, Malloy MJ, Kane JP. Smoking Classification Using Novel Plasma Cytokines by implementing Machine Learning and Statistical Methods. Proceedings. International Conference on Computational Science and Computational Intelligence 2024. PMID: 39450278


  3. Kane JP, Ames A, Patel RV, Voity K, Narine R, Perotte R, Gelman S, McCarthy D, Nemetski SM. Trends in cannabis use in New Jersey: Effects of COVID-19 and cannabis legalization. Journal of the American College of Emergency Physicians open 2024. PMID: 38883691


  4. Weng LC, Khurshid S, Hall AW, Nauffal V, Morrill VN, Sun YV, Rämö JT, Beer D, Lee S, Nadkarni G, Johnson R, Andreasen L, Clayton A, Pullinger CR, Yoneda ZT, Friedman DJ, Hyman MC, Judy RL, Skanes AC, Orland KM, Jordà P, Treu TM, Oetjens MT, Subbiah R, Hartmann JP, May HT, Kane JP, Issa TZ, Nafissi NA, Leong-Sit P, Dubé MP, Roselli C, Choi SH, FinnGen, Million Veteran Program, Regeneron Genetics Center, Tardif JC, Khan HR, Knight S, Svendsen JH, Walker B, Karlsson Linnér R, Gaziano JM, Tadros R, Fatkin D, Rader DJ, Shah SH, Roden DM, Marcus GM, Loos RJF, Damrauer SM, Haggerty CM, Cho K, Palotie A, Olesen MS, Eckhardt LL, Roberts JD, Cutler MJ, Shoemaker MB, Wilson PWF, Ellinor PT, Lubitz SA. Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. Circulation. Genomic and precision medicine 2024. PMID: 38804128


  5. Rakic JM, Pullinger CR, Van Blarigan EL, Movsesyan I, Stock EO, Malloy MJ, Kane JP. APOL1 Risk Variants Associate With the Prevalence of Stroke in African American Current and Past Smokers. Journal of the American Heart Association 2023. PMID: 38084718


  6. Mustra Rakic J, Pullinger CR, Van Blarigan EL, Movsesyan I, Oestreicher Stock E, Malloy MJ, Kane JP. APOL1 Risk Variants Associate with the Prevalence of Stroke in African American Current and Past Smokers. medRxiv : the preprint server for health sciences 2023. PMID: 37162992


  7. Cuchel M, Lee PC, Hudgins LC, Duell PB, Ahmad Z, Baum SJ, Linton MF, de Ferranti SD, Ballantyne CM, Larry JA, Hemphill LC, Kindt I, Gidding SS, Martin SS, Moriarty PM, Thompson PP, Underberg JA, Guyton JR, Andersen RL, Whellan DJ, Benuck I, Kane JP, Myers K, Howard W, Staszak D, Jamison A, Card MC, Bourbon M, Chora JR, Rader DJ, Knowles JW, Wilemon K, McGowan MP. Contemporary Homozygous Familial Hypercholesterolemia in the United States: Insights From the CASCADE FH Registry. Journal of the American Heart Association 2023. PMID: 37119068


  8. Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM, Luna SE, Prothro KP, Mitchell SR, Laurie CA, Broome JG, Taylor KD, Guo X, Sinner MF, von Falkenhausen AS, K??b S, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Hou L, Lloyd-Jones DM, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Palmer ND, Freedman BI, Bowden DW, Cho MH, DeMeo DL, Vasan RS, Yanek LR, Becker LC, Kardia SLR, Peyser PA, He J, Rienstra M, Van der Harst P, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Cutler MJ, Knight S, Muhlestein JB, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Tracy RP, Konkle BA, Johnsen JM, Wheeler MM, Smith JG, Melander O, Nilsson PM, Custer BS, Duggirala R, Curran JE, Blangero J, McGarvey S, Williams LK, Xiao S, Yang M, Gu CC, Chen YI, Lee WJ, Marcus GM, Kane JP, Pullinger CR, Shoemaker MB, Darbar D, Roden DM, Albert C, Kooperberg C, Zhou Y, Manson JE, Desai P, Johnson AD, Mathias RA, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Satpathy AT, Natarajan P, Kitzman JO, Whitsel EA, Reiner AP, Bick AG, Jaiswal S. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Nature 2023. PMID: 37046083


  9. Jun G, English A, Metcalf G, Yang J, Chaisson M, Pankratz N, Menon V, Salerno W, Krasheninina O, Smith A, Lane J, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, Kottapalli K, Arnett D, Ashley-Koch A, Auer P, Beutel K, Bis J, Blangero J, Bowden D, Brody J, Cade B, Chen YI, Cho M, Curran J, Fornage M, Frredman B, Fingerlin T, Gelb B, Hou L, Hung YJ, Kane JP, Kaplan R, Kim W, Loos R, Marcus G, Mathias R, McGarvey S, Montgomery C, Naseri T, Nouraie S, Preuss M, Palmer N, Peyser P, Raffield L, Ratan A, Redline S, Reupena M, Rotter J, Rich S, Rienstra M, Ruczinski I, Sankaran V, Schwartz D, Seidman C, Seidman J, Silverman E, Smith J, Stilp A, Taylor K, Telen M, Weiss S, Williams LK, Wu B, Yanek L, Zhang Y, Lasky-Su J, Gingras MC, Dutcher S, Eichler E, Gabriel S, Germer S, Kim R, Martinez K, Nickerson D, Luo J, Reiner A, Gibbs R, Boerwinkle E, Abecasis G, Sedlazeck F. Structural variation across 138,134 samples in the TOPMed consortium. Research square 2023. PMID: 36778386


  10. Jun G, English AC, Metcalf GA, Yang J, Chaisson MJ, Pankratz N, Menon VK, Salerno WJ, Krasheninina O, Smith AV, Lane JA, Blackwell T, Kang HM, Salvi S, Meng Q, Shen H, Pasham D, Bhamidipati S, Kottapalli K, Arnett DK, Ashley-Koch A, Auer PL, Beutel KM, Bis JC, Blangero J, Bowden DW, Brody JA, Cade BE, Chen YI, Cho MH, Curran JE, Fornage M, Freedman BI, Fingerlin T, Gelb BD, Hou L, Hung YJ, Kane JP, Kaplan R, Kim W, Loos RJF, Marcus GM, Mathias RA, McGarvey ST, Montgomery C, Naseri T, Nouraie SM, Preuss MH, Palmer ND, Peyser PA, Raffield LM, Ratan A, Redline S, Reupena S, Rotter JI, Rich SS, Rienstra M, Ruczinski I, Sankaran VG, Schwartz DA, Seidman CE, Seidman JG, Silverman EK, Smith JA, Stilp A, Taylor KD, Telen MJ, Weiss ST, Williams LK, Wu B, Yanek LR, Zhang Y, Lasky-Su J, Gingras MC, Dutcher SK, Eichler EE, Gabriel S, Germer S, Kim R, Viaud-Martinez KA, Nickerson DA, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Luo J, Reiner A, Gibbs RA, Boerwinkle E, Abecasis G, Sedlazeck FJ. Structural variation across 138,134 samples in the TOPMed consortium. bioRxiv : the preprint server for biology 2023. PMID: 36747810


  11. Mustra Rakic J, Zeng S, Rohdin-Bibby L, Van Blarigan EL, Liu X, Ma S, Kane JP, Redberg RF, Turino GM, Oestreicher Stock E, Arjomandi M. Elastin Degradation and Lung Function Deterioration with Remote Secondhand Tobacco Smoke Exposure in Never-smokers. Chronic obstructive pulmonary diseases (Miami, Fla.) 2022. PMID: 35700534


  12. Dong W, Wong KH, Liu Y, Levy-Sakin M, Hung WC, Li M, Li B, Jin SC, Choi J, Lopez-Giraldez F, Vaka D, Poon A, Chu C, Lao R, Balamir M, Movsesyan I, Malloy MJ, Zhao H, Kwok PY, Kane JP, Lifton RP, Pullinger CR. Whole Exome Sequencing Reveals Damaging Gene Variants Associated with Hypoalphalipoproteinemia. "Are Telehealth Visits Feasible for Vulnerable Patients?" 2022. PMID: 35460704


  13. Kane JP, Pullinger CR, Goldfine ID, Malloy MJ. Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus. Current opinion in pharmacology 2021. PMID: 34562838


  14. Saharan SS, Nagar P, Creasy KT, Stock EO, Feng J, Malloy MJ, Kane JP. Machine learning and statistical approaches for classification of risk of coronary artery disease using plasma cytokines. BioData mining 2021. PMID: 33858484


  15. Pullinger CR, O'Connor PM, Naya-Vigne JM, Kunitake ST, Movsesyan I, Frost PH, Malloy MJ, Kane JP. Levels of Prebeta-1 High-Density Lipoprotein Are a Strong Independent Positive Risk Factor for Coronary Heart Disease and Myocardial Infarction: A Meta-Analysis. Journal of the American Heart Association 2021. PMID: 33728928


  16. Gill PK, Dron JS, Dilliott AA, McIntyre AD, Cao H, Wang J, Movsesyan IG, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia. Journal of clinical lipidology 2020. PMID: 33303403


  17. Dron JS, Dilliott AA, Lawson A, McIntyre AD, Davis BD, Wang J, Cao H, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia. Arteriosclerosis, thrombosis, and vascular biology 2020. PMID: 32580631


  18. Jones GM, Caccavello R, Palii SP, Pullinger CR, Kane JP, Mulligan K, Gugliucci A, Schwarz JM. Separation of postprandial lipoproteins: improved purification of chylomicrons using an ApoB100 immunoaffinity method. Journal of lipid research 2019. PMID: 31888979


  19. Wong KHY, Levy-Sakin M, Ma W, Gonzaludo N, Mak ACY, Vaka D, Poon A, Chu C, Lao R, Balamir M, Grenville Z, Wong N, Kane JP, Kwok PY, Malloy MJ, Pullinger CR. Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis. Molecular genetics & genomic medicine 2019. PMID: 31617323


  20. Roberts G, Lloyd JJ, Kane JPM, Durcan R, Lawley S, Howe K, Petrides GS, O'Brien JT, Thomas AJ. Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age. "Are Telehealth Visits Feasible for Vulnerable Patients?" 2019. PMID: 31529384


  21. Dron JS, Wang J, McIntyre AD, Cao H, Robinson JF, Duell B, Manjoo P, Feng J, Movsesyan I, Malloy MJ, Pullinger CR, Kane J, Hegele RA. Partial LPL deletions: rare copy-number variants contributing towards the polygenic form of severe hypertriglyceridemia. Journal of lipid research 2019. PMID: 31519763


  22. Creasy KT, Kane JP, Malloy MJ. Emerging roles of HDL in immune function. Current opinion in lipidology 2018. PMID: 30382953


  23. Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Severe hypertriglyceridemia is primarily polygenic. Journal of clinical lipidology 2018. PMID: 30466821


  24. Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtimäki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytikäinen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, März W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, Müller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Paré G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribasés M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Seppälä I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotoodehnia N, Stricker BH, Sun A, Sun H, Svendsen JH, Tanaka T, Tanriverdi K, Taylor KD, Teder-Laving M, Teumer A, Thériault S, Trompet S, Tucker NR, Tveit A, Uitterlinden AG, Van Der Harst P, Van Gelder IC, Van Wagoner DR, Verweij N, Vlachopoulou E, Völker U, Wang B, Weeke PE, Weijs B, Weiss R, Weiss S, Wells QS, Wiggins KL, Wong JA, Woo D, Worrall BB, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Lubitz SA, Lunetta KL, Ellinor PT. Multi-ethnic genome-wide association study for atrial fibrillation. Nature genetics 2018. PMID: 29892015


  25. Stock EO, Ferrara CT, O'Connor PM, Naya-Vigne JM, Frost PH, Malloy MJ, Kane JP, Pullinger CR. Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia. Journal of clinical lipidology 2017. PMID: 29198898


  26. Quinn AG, Schwemberger R, Stock EO, Movsesyan I, Axtell A, Chang S, Ishida BY, Malloy MJ, Kane JP, Pullinger CR. Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients. Journal of clinical lipidology 2017. PMID: 28558949


  27. Hayne CK, Lafferty MJ, Eglinger BJ, Kane JP, Neher SB. Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake. Biochemistry 2017. PMID: 27984852


  28. Kane JP, Malloy MJ. Lipoproteins and amyloid vascular disease. Current opinion in lipidology 2016. PMID: 27805977


  29. Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J, Wattimena D, Rietveld T, Pullinger CR, Christoffersen C, Dahlbäck B, Kane JP, Mulder M, Sijbrands EJ. Familial hypercholesterolaemia: cholesterol efflux and coronary disease. European journal of clinical investigation 2016. PMID: 27208892


  30. Kane JP. Infectious basophilia? American journal of hematology 2016. PMID: 26572775


  31. Kane JP, Malloy MJ. Emerging molecular strategies for management of dyslipidemias. Current opinion in lipidology 2015. PMID: 26780015


  32. Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. Journal of the American College of Cardiology 2015. PMID: 26564598


  33. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. eLife 2015. PMID: 26473617


  34. Pullinger CR, Stock EO, Movsesyan I, Malloy MJ, Frost PH, Tripuraneni R, Quinn AG, Ishida BY, Schaefer EJ, Asztalos BF, Kane JP. Identification and metabolic profiling of patients with lysosomal acid lipase deficiency. Journal of clinical lipidology 2015. PMID: 26350820


  35. Kane JP, Malloy MJ, Pullinger CR. HDL cholesterol efflux capacity and cardiovascular events. The New England journal of medicine 2015. PMID: 25946301


  36. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circulation. Cardiovascular genetics 2015. PMID: 25632026


  37. Malloy MJ, Kane JP. Congenital absence of apolipoprotein E and neurological function-reply. JAMA neurology 2014. PMID: 25486213


  38. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA neurology 2014. PMID: 25111166


  39. Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM, Ryan RO. Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). Arteriosclerosis, thrombosis, and vascular biology 2014. PMID: 25127531


  40. Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG. Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency. Journal of hepatology 2014. PMID: 24993530


  41. Arndt C, Leclercq I, Nazeyrollas P, Durlach A, Ducasse A, Movesayan I, Socquard E, Clavel C, Malloy MM, Pullinger CR, Kane JP, Durlach V. Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients. Diabetes & metabolism 2014. PMID: 24852509


  42. Rowland CM, Pullinger CR, Luke MM, Shiffman D, Green L, Movsesyan I, Devlin JJ, Malloy MJ, Kane JP, Undas A. Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties. Thrombosis research 2014. PMID: 24502962


  43. Roberts JD, Hsu JC, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Olgin JE, Marcus GM. Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation. Journal of cardiovascular electrophysiology 2013. PMID: 24237655


  44. Pullinger CR, Goldfine ID, Tanyolaç S, Movsesyan I, Faynboym M, Durlach V, Chiefari E, Foti DP, Frost PH, Malloy MJ, Brunetti A, Kane JP. Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population. Metabolic syndrome and related disorders 2013. PMID: 24148075


  45. Kane JP, Malloy MJ. Needed: a better understanding of the antiatherogenic properties of HDL. Current opinion in lipidology 2013. PMID: 24005220


  46. Kane JP. New horizons in lipid management. Journal of the American College of Cardiology 2013. PMID: 23770169


  47. Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC. Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression. Journal of the American Heart Association 2013. PMID: 23686369


  48. Balwani M, Breen C, Enns GM, Deegan PB, Honzík T, Jones S, Kane JP, Malinova V, Sharma R, Stock EO, Valayannopoulos V, Wraith JE, Burg J, Eckert S, Schneider E, Quinn AG. Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease. Hepatology (Baltimore, Md.) 2013. PMID: 23348766


  49. Malloy MJ, Kane JP. Hyperlipidemia and cardiovascular disease. Current opinion in lipidology 2012. PMID: 23160407


  50. Kane JP, Malloy MJ. Prebeta-1 HDL and coronary heart disease. Current opinion in lipidology 2012. PMID: 22517613


  51. Charles MA, Kane JP. New molecular insights into CETP structure and function: a review. Journal of lipid research 2012. PMID: 22679067


  52. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. American journal of human genetics 2012. PMID: 22521419


  53. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart rhythm 2012. PMID: 22300662


  54. Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C. Polymorphisms and noncardioembolic stroke in three case-control studies. Cerebrovascular diseases (Basel, Switzerland) 2011. PMID: 22134093


  55. Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A. Association between regulator of G protein signaling 9-2 and body weight. PloS one 2011. PMID: 22132185


  56. Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ. Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease. The American journal of cardiology 2011. PMID: 21757044


  57. DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC. Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study. Pediatric blood & cancer 2011. PMID: 21793187


  58. Ruaño G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD. Mechanisms of statin-induced myalgia assessed by physiogenomic associations. Atherosclerosis 2011. PMID: 21868014


  59. Francone OL, Ishida BY, de la Llera-Moya M, Royer L, Happe C, Zhu J, Chalkey RJ, Schaefer P, Cox C, Burlingame A, Kane JP, Rothblat GH. Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels. Journal of lipid research 2011. PMID: 21771977


  60. Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA 2011. PMID: 21364139


  61. Durlach V, Durlach A, Movesayan I, Socquard E, Zellner C, Clavel C, Nazeyrollas P, Malloy MJ, Pullinger CR, Kane JP, Ducasse A, Aouizerat BE. Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients. Diabetes & metabolism 2010. PMID: 21145773


  62. Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. Journal of lipid research 2010. PMID: 20978167


  63. Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pharmacogenomics 2010. PMID: 20602615


  64. Pullinger CR, Aouizerat BE, Gay C, Coggins T, Movsesyan I, Davis H, Kane JP, Portillo C, Lee KA. Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults. Metabolic syndrome and related disorders 2010. PMID: 20235745


  65. Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ. Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. Atherosclerosis 2010. PMID: 20605575


  66. Pan J, Shilian P, Ishida B, Wu X, Kane JP, Malloy MJ, Charles MA. Effect of niacin on preß-1 high-density lipoprotein levels in diabetes. Metabolism: clinical and experimental 2010. PMID: 20303127


  67. Fujimoto VY, Kane JP, Ishida BY, Bloom MS, Browne RW. High-density lipoprotein metabolism and the human embryo. Human reproduction update 2010. PMID: 19700490


  68. Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID. Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects. Metabolic syndrome and related disorders 2009. PMID: 19656007


  69. Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis 2009. PMID: 19880117


  70. Ortiz-Muñoz G, Houard X, Martín-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O. HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009. PMID: 19417089


  71. Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL. Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. The British journal of ophthalmology 2009. PMID: 19304587


  72. Zhu J, Gardner J, Pullinger CR, Kane JP, Thompson JF, Francone OL. Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. Journal of lipid research 2009. PMID: 19237735


  73. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Human molecular genetics 2008. PMID: 19091795


  74. Meyer TE, Shiffman D, Morrison AC, Rowland CM, Louie JZ, Bare LA, Ross DA, Arellano AR, Chasman DI, Ridker PM, Pankow JS, Coresh J, Malloy MJ, Kane JP, Ellis SG, Devlin JJ, Boerwinkle E. GOSR2 Lys67Arg is associated with hypertension in whites. American journal of hypertension 2008. PMID: 19057520


  75. Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L, Ramírez-Jiménez S, de Bruin TW, Tusié-Luna T, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. Galanin preproprotein is associated with elevated plasma triglycerides. Arteriosclerosis, thrombosis, and vascular biology 2008. PMID: 18988886


  76. Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. PloS one 2008. PMID: 18682748


  77. van der Net JB, Versmissen J, Oosterveer DM, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kane JP, Kastelein JJ, Sijbrands EJ. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. Atherosclerosis 2008. PMID: 18775537


  78. Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P. WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. American journal of human genetics 2008. PMID: 18674750


  79. van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJ, Kane JP, Sijbrands EJ. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. European heart journal 2008. PMID: 18599554


  80. Pullinger CR, Aouizerat BE, Movsesyan I, Durlach V, Sijbrands EJ, Nakajima K, Poon A, Dallinga-Thie GM, Hattori H, Green LL, Kwok PY, Havel RJ, Frost PH, Malloy MJ, Kane JP. An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. Journal of lipid research 2008. PMID: 18441017


  81. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS genetics 2008. PMID: 18369459


  82. Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nature genetics 2007. PMID: 17994020


  83. Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Arteriosclerosis, thrombosis, and vascular biology 2007. PMID: 17975119


  84. Bare LA, Morrison AC, Rowland CM, Shiffman D, Luke MM, Iakoubova OA, Kane JP, Malloy MJ, Ellis SG, Pankow JS, Willerson JT, Devlin JJ, Boerwinkle E. Five common gene variants identify elevated genetic risk for coronary heart disease. Genetics in medicine : official journal of the American College of Medical Genetics 2007. PMID: 18073581


  85. Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology 2007. PMID: 17721242


  86. Davidson MH, Smith J, Scott R, Small R, Choi J, Ishida BY, Kane JP. Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067. Journal of clinical lipidology 2007. PMID: 21291691


  87. Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky ML, Devlin JJ, Ellis SG. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology 2007. PMID: 17569884


  88. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, Pankow JS, Devlin JJ, Willerson JT, Boerwinkle E. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. American journal of epidemiology 2007. PMID: 17443022


  89. Wung SF, Kulkarni MV, Pullinger CR, Malloy MJ, Kane JP, Aouizerat BE. The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion. Lipids in health and disease 2006. PMID: 16822320


  90. Shiffman D, Rowland CM, Louie JZ, Luke MM, Bare LA, Bolonick JI, Young BA, Catanese JJ, Stiggins CF, Pullinger CR, Topol EJ, Malloy MJ, Kane JP, Ellis SG, Devlin JJ. Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. Arteriosclerosis, thrombosis, and vascular biology 2006. PMID: 16690874


  91. Ishida BY, Duncan KG, Bailey KR, Kane JP, Schwartz DM. High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture. The British journal of ophthalmology 2006. PMID: 16622093


  92. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C. Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS biology 2005. PMID: 16122350


  93. Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP. Identification of four gene variants associated with myocardial infarction. American journal of human genetics 2005. PMID: 16175505


  94. Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C. Parotid secretory protein is an HDL-associated protein with anticandidal activity. American journal of physiology. Regulatory, integrative and comparative physiology 2005. PMID: 15637169


  95. Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP. Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors. Human mutation 2005. PMID: 15580557


  96. Albert TS, Duchateau PN, Deeb SS, Pullinger CR, Cho MH, Heilbron DC, Malloy MJ, Kane JP, Brown BG. Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL. Journal of lipid research 2004. PMID: 15604524


  97. Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR. Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL. Atherosclerosis 2004. PMID: 15306172


  98. Stoller ML, Meng MV, Abrahams HM, Kane JP. The primary stone event: a new hypothesis involving a vascular etiology. The Journal of urology 2004. PMID: 15076312


  99. Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. Journal of lipid research 2003. PMID: 14594998


  100. Huuskonen J, Abedin M, Vishnu M, Pullinger CR, Baranzini SE, Kane JP, Fielding PE, Fielding CJ. Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts. Biochemical and biophysical research communications 2003. PMID: 12804586


  101. Aouizerat BE, Kane JP. Apolipoprotein A-II: active or passive role in familial combined hyperlipidemia. Circulation research 2003. PMID: 12805235


  102. Pullinger CR, Kane JP, Malloy MJ. Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders. Expert review of cardiovascular therapy 2003. PMID: 15030301


  103. Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, Malloy MJ, Kane JP. Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. Journal of lipid research 2003. PMID: 12671030


  104. Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP. The effects of physical exercise on plasma prebeta-1 high-density lipoprotein. Metabolism: clinical and experimental 2003. PMID: 12701055


  105. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E. Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature 2003. PMID: 12621437


  106. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. The Journal of clinical investigation 2002. PMID: 12093894


  107. Gaffney D, Pullinger CR, O'Reilly DS, Hoffs MS, Cameron I, Vass JK, Kulkarni MV, Kane JP, Schumaker VN, Watts GF, Packard CJ. Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding. Clinica chimica acta; international journal of clinical chemistry 2002. PMID: 12031600


  108. Duncan KG, Bailey KR, Kane JP, Schwartz DM. Human retinal pigment epithelial cells express scavenger receptors BI and BII. Biochemical and biophysical research communications 2002. PMID: 11944916


  109. Kane JP. Does hypertriglyceridemia present an indication for pioglitazone therapy in diabetes? Diabetes technology & therapeutics 2002. PMID: 12079618


  110. Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. Journal of lipid research 2001. PMID: 11290834


  111. Malloy MJ, Kane JP. A risk factor for atherosclerosis: triglyceride-rich lipoproteins. Advances in internal medicine 2001. PMID: 11795072


  112. Drmanac S, Heilbron DC, Pullinger CR, Jafari M, Gietzen D, Ukrainczyk T, Cho MH, Frost PH, Siradze K, Drmanac RT, Kane JP, Malloy MJ. Elevated baseline triglyceride levels modulate effects of HMGCoA reductase inhibitors on plasma lipoproteins. Journal of cardiovascular pharmacology and therapeutics 2001. PMID: 11452336


  113. Frossard PM, Malloy MJ, Lestringant GG, Kane JP. Haplotypes of the human renin gene associated with essential hypertension and stroke. Journal of human hypertension 2001. PMID: 11224002


  115. Duchateau PN, Movsesyan I, Yamashita S, Sakai N, Hirano K, Schoenhaus SA, O'Connor-Kearns PM, Spencer SJ, Jaffe RB, Redberg RF, Ishida BY, Matsuzawa Y, Kane JP, Malloy MJ. Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects. Journal of lipid research 2000. PMID: 10946010


  116. Pullinger CR, Hakamata H, Duchateau PN, Eng C, Aouizerat BE, Cho MH, Fielding CJ, Kane JP. Analysis of hABC1 gene 5' end: additional peptide sequence, promoter region, and four polymorphisms. Biochemical and biophysical research communications 2000. PMID: 10799318


  117. Nishino M, Malloy MJ, Naya-Vigne J, Russell J, Kane JP, Redberg RF. Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women. Journal of the American College of Cardiology 2000. PMID: 10676675


  118. Frossard PM, Lestringant GG, Malloy MJ, Kane JP. Human renin gene BglI dimorphism associated with hypertension in two independent populations. Clinical genetics 1999. PMID: 10665661


  119. Frossard PM, Kane JP, Malloy MJ, Bener A. Renin gene MboI dimorphism is a discriminator for hypertension in hyperlipidaemic subjects. Hypertension research : official journal of the Japanese Society of Hypertension 1999. PMID: 10580395


  120. Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome research 1999. PMID: 10523522


  121. Connor JP, Ferrer K, Kane JP, Goldberg JM. Evaluation of Langerhans' cells in the cervical epithelium of women with cervical intraepithelial neoplasia. Gynecologic oncology 1999. PMID: 10502439


  123. Pullinger CR, Gaffney D, Gutierrez MM, Malloy MJ, Schumaker VN, Packard CJ, Kane JP. The apolipoprotein B R3531C mutation. Characteristics of 24 subjects from 9 kindreds. Journal of lipid research 1999. PMID: 9925662


  124. Cheng S, Pallaud C, Grow MA, Scharf SJ, Erlich HA, Klitz W, Pullinger CR, Malloy MJ, Kane JP, Siest G, Visvikis S. A multilocus genotyping assay for cardiovascular disease. Clinical chemistry and laboratory medicine 1998. PMID: 9806460


  125. O'Connor PM, Zysow BR, Schoenhaus SA, Ishida BY, Kunitake ST, Naya-Vigne JM, Duchateau PN, Redberg RF, Spencer SJ, Mark S, Mazur M, Heilbron DC, Jaffe RB, Malloy MJ, Kane JP. Prebeta-1 HDL in plasma of normolipidemic individuals: influences of plasma lipoproteins, age, and gender. Journal of lipid research 1998. PMID: 9548598


  126. Schwartz GG, Oliver MF, Ezekowitz MD, Ganz P, Waters D, Kane JP, Texter M, Pressler ML, Black D, Chaitman BR, Olsson AG. Rationale and design of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study that evaluates atorvastatin in unstable angina pectoris and in non-Q-wave acute myocardial infarction. The American journal of cardiology 1998. PMID: 9514453


  127. Malloy MJ, Kane JP. Aggressive medical therapy for the prevention and treatment of coronary artery disease. Disease-a-month : DM 1998. PMID: 9457050


  128. Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP, Malloy MJ, Korach KS, Rubanyi GM. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation 1997. PMID: 9396482


  129. Duchateau PN, Pullinger CR, Orellana RE, Kunitake ST, Naya-Vigne J, O'Connor PM, Malloy MJ, Kane JP. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. The Journal of biological chemistry 1997. PMID: 9325276


  130. O'Connor PM, Naya-Vigne JM, Duchateau PN, Ishida BY, Mazur M, Schoenhaus SA, Zysow BR, Malloy MJ, Kunitake ST, Kane JP. Measurement of prebeta-1 HDL in human plasma by an ultrafiltration-isotope dilution technique. Analytical biochemistry 1997. PMID: 9299021


  131. Pullinger CR, Malloy MJ, Shahidi AK, Ghassemzadeh M, Duchateau P, Villagomez J, Allaart J, Kane JP. A novel apolipoprotein C-III variant, apoC-III(Gln38-->Lys), associated with moderate hypertriglyceridemia in a large kindred of Mexican origin. Journal of lipid research 1997. PMID: 9323592


  132. Hennessy LK, Kunitake ST, Jarvis M, Hamilton RL, Endeman G, Protter A, Kane JP. Isolation of subpopulations of high density lipoproteins: three particle species containing apoE and two species devoid of apoE that have affinity for heparin. Journal of lipid research 1997. PMID: 9323595


  133. Phillips ML, Pullinger C, Kroes I, Kroes J, Hardman DA, Chen G, Curtiss LK, Gutierrez MM, Kane JP, Schumaker VN. A single copy of apolipoprotein B-48 is present on the human chylomicron remnant. Journal of lipid research 1997. PMID: 9215545


  134. van Antwerpen R, Chen GC, Pullinger CR, Kane JP, LaBelle M, Krauss RM, Luna-Chavez C, Forte TM, Gilkey JC. Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety. Journal of lipid research 1997. PMID: 9144081


  135. Malloy MJ, Kane JP. Aggressive medical therapy for the prevention and treatment of coronary artery disease. Advances in internal medicine 1997. PMID: 9048115


  136. Pullinger CR, Love JA, Liu W, Hennessy LK, Ghassemzadeh M, Newcomb KC, Illingworth DR, Kane JP. The apolipoprotein B Q3405E polymorphism has no effect on its low-density-lipoprotein receptor binding affinity. Human genetics 1996. PMID: 8931699


  137. Hausmann D, Johnson JA, Sudhir K, Mullen WL, Friedrich G, Fitzgerald PJ, Chou TM, Ports TA, Kane JP, Malloy MJ, Yock PG. Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: correlation with high density lipoproteins. Journal of the American College of Cardiology 1996. PMID: 8636537


  138. Chatterton JE, Schlapfer P, Bütler E, Gutierrez MM, Puppione DL, Pullinger CR, Kane JP, Curtiss LK, Schumaker VN. Identification of apolipoprotein B100 polymorphisms that affect low-density lipoprotein metabolism: description of a new approach involving monoclonal antibodies and dynamic light scattering. Biochemistry 1995. PMID: 7626627


  139. Read TE, Grunfeld C, Kumwenda ZL, Calhoun MC, Kane JP, Feingold KR, Rapp JH. Triglyceride-rich lipoproteins prevent septic death in rats. The Journal of experimental medicine 1995. PMID: 7790821


  140. Pullinger CR, Hennessy LK, Chatterton JE, Liu W, Love JA, Mendel CM, Frost PH, Malloy MJ, Schumaker VN, Kane JP. Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity. The Journal of clinical investigation 1995. PMID: 7883971


  141. Sudhir K, Ports TA, Amidon TM, Goldberger JJ, Bhushan V, Kane JP, Yock P, Malloy MJ. Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia. Circulation 1995. PMID: 7867176


  142. Insull W, Davidson MH, Demke DM, Dujovne CA, Eckert SM, Ginsberg D, Goldberg AC, Hodis HN, Hughes TA, Kane JP. The effects of colestipol tablets compared with colestipol granules on plasma cholesterol and other lipids in moderately hypercholesterolemic patients. Atherosclerosis 1995. PMID: 7772081


  143. Read TE, Grunfeld C, Kumwenda Z, Calhoun MC, Kane JP, Feingold KR, Rapp JH. Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats. Surgery 1995. PMID: 7809838


  144. Rapp JH, Lespine A, Hamilton RL, Colyvas N, Chaumeton AH, Tweedie-Hardman J, Kotite L, Kunitake ST, Havel RJ, Kane JP. Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arteriosclerosis and thrombosis : a journal of vascular biology 1994. PMID: 7947602


  145. Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. The Journal of experimental medicine 1994. PMID: 8064223


  146. Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP. The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred. Clinical genetics 1994. PMID: 7923858


  147. Kunitake ST, Carilli CT, Lau K, Protter AA, Naya-Vigne J, Kane JP. Identification of proteins associated with apolipoprotein A-I-containing lipoproteins purified by selected-affinity immunosorption. Biochemistry 1994. PMID: 8117655


  148. Malloy MJ, Kane JP. Medical management of hyperlipidemic states. Advances in internal medicine 1994. PMID: 8140966


  149. Read TE, Harris HW, Grunfeld C, Feingold KR, Kane JP, Rapp JH. The protective effect of serum lipoproteins against bacterial lipopolysaccharide. European heart journal 1993. PMID: 8131781


  150. Read TE, Harris HW, Grunfeld C, Feingold KR, Calhoun MC, Kane JP, Rapp JH. Chylomicrons enhance endotoxin excretion in bile. Infection and Immunity 1993. PMID: 8335381


  153. Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF, Rapp JH. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. The Journal of clinical investigation 1993. PMID: 8450032


  154. Pullinger CR, Zysow BR, Hennessy LK, Frost PH, Malloy MJ, Kane JP. Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. Human molecular genetics 1993. PMID: 8490626


  155. Kunitake ST, Jarvis MR, Hamilton RL, Kane JP. Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America 1992. PMID: 1495991


  157. Pullinger CR, Hillas E, Hardman DA, Chen GC, Naya-Vigne JM, Iwasa JA, Hamilton RL, Lalouel JM, Williams RR, Kane JP. Two apolipoprotein B gene defects in a kindred with hypobetalipoproteinemia, one of which results in a truncated variant, apoB-61, in VLDL and LDL. Journal of lipid research 1992. PMID: 1619363


  158. Colyvas N, Rapp JH, Phillips NR, Stoney R, Perez S, Kane JP, Havel RJ. Relation of plasma lipid and apoprotein levels to progressive intimal hyperplasia after arterial endarterectomy. Circulation 1992. PMID: 1555272


  159. Malloy MJ, Kane JP. Drs malloy and kane respond. The Western journal of medicine 1992. PMID: 18750862


  160. Eichbaum EB, Harris HW, Kane JP, Rapp JH. Chylomicrons can inhibit endotoxin activity in vitro. The Journal of surgical research 1991. PMID: 1758174


  161. Hardman DA, Pullinger CR, Hamilton RL, Kane JP, Malloy MJ. Molecular and metabolic basis for the metabolic disorder normotriglyceridemic abetalipoproteinemia. The Journal of clinical investigation 1991. PMID: 1939657


  162. Malloy MJ, Frost PH, Kane JP. Niacin--the long and the short of it. The Western journal of medicine 1991. PMID: 1771892


  163. Harris HW, Eichbaum EB, Kane JP, Rapp JH. Detection of endotoxin in triglyceride-rich lipoproteins in vitro. The Journal of laboratory and clinical medicine 1991. PMID: 1856581


  165. Ameis D, Kobayashi J, Davis RC, Ben-Zeev O, Malloy MJ, Kane JP, Lee G, Wong H, Havel RJ, Schotz MC. Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene. The Journal of clinical investigation 1991. PMID: 2010533


  166. Wardell MR, Rall SC, Schaefer EJ, Kane JP, Weisgraber KH. Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity. Journal of lipid research 1991. PMID: 1648586


  167. Kane JP, Malloy MJ, Ports TA, Phillips NR, Diehl JC, Havel RJ. Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens. JAMA 1990. PMID: 2243428


  168. Kunitake ST, Young SG, Chen GC, Pullinger CR, Zhu S, Pease RJ, Scott J, Hass P, Schilling J, Kane JP. Conformation of apolipoprotein B-100 in the low density lipoproteins of tangier disease. Identification of localized conformational response to triglyceride content. The Journal of biological chemistry 1990. PMID: 1701170


  169. Kunitake ST, Chen GC, Kung SF, Schilling JW, Hardman DA, Kane JP. Pre-beta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis. Arteriosclerosis (Dallas, Tex.) 1990. PMID: 2136993


  170. Kane JP, Malloy MJ. Treatment of hyperlipidemia. Annual review of medicine 1990. PMID: 2184745


  171. Chen GC, Zhu S, Hardman DA, Schilling JW, Lau K, Kane JP. Structural domains of human apolipoprotein B-100. Differential accessibility to limited proteolysis of B-100 in low density and very low density lipoproteins. The Journal of biological chemistry 1989. PMID: 2668286


  172. Chen GC, Hardman DA, Hamilton RL, Mendel CM, Schilling JW, Zhu S, Lau K, Wong JS, Kane JP. Distribution of lipid-binding regions in human apolipoprotein B-100. Biochemistry 1989. PMID: 2730877


  173. Rapp JH, Harris HW, Hamilton RL, Krupski WC, Reilly LM, Ehrenfeld WK, Stoney RJ, Goldstone J, Kane JP. Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report. Journal of vascular surgery 1989. PMID: 2911145


  174. Sernatinger J, Hoffman A, Hardman D, Kane JP, Levy JA. Neutralization of mouse xenotropic virus by lipoproteins involves binding to the virions. The Journal of general virology 1988. PMID: 2844973


  175. Mendel CM, Kunitake ST, Hong K, Erickson SK, Kane JP, Kempner ES. Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes. Biochimica et biophysica acta 1988. PMID: 2839235


  176. Coleman RT, Cawthon RM, Malloy MJ, Kane JP, Nakashima PF, Frossard PM. Bsm I RFLP at the human apolipoprotein AI-CIII gene complex locus. Nucleic acids research 1988. PMID: 2895918


  177. Coleman RT, Malloy MJ, Kane JP, Frossard PM. NcoI dimorphic site located 8kb 3' to the human apolipoprotein AIV (APOA4) gene. Nucleic acids research 1988. PMID: 2894008


  178. Gustafson A, Kane JP, Havel RJ. Determinants of kallikrein proteolysis of apolipoprotein B-100 in human blood plasma. European journal of clinical investigation 1988. PMID: 3130263


  179. Mendel CM, Kunitake ST, Kane JP, Kempner ES. Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes. The Journal of biological chemistry 1988. PMID: 2826475


  180. Kane JP, Malloy MJ. When to treat hyperlipidemia. Advances in internal medicine 1988. PMID: 3278503


  181. Hardman DA, Protter AA, Schilling JW, Kane JP. Carboxyl terminal analysis of human B-48 protein confirms the novel mechanism proposed for chain termination. Biochemical and biophysical research communications 1987. PMID: 3426612


  182. Malloy MJ, Kane JP, Kunitake ST, Tun P. Complementarity of colestipol, niacin, and lovastatin in treatment of severe familial hypercholesterolemia. Annals of internal medicine 1987. PMID: 3662275


  183. Frossard PM, Coleman RT, Malloy MJ, Kane JP, Levy-Wilson B, Appleby VA. Human apolipoprotein CI (apoC1) gene locus: DraI dimorphic site. Nucleic acids research 1987. PMID: 2881281


  184. Frossard PM, Lim DW, Coleman RT, Funke H, Assmann G, Malloy MJ, Kane JP. Human apolipoprotein CI (ApoC1) gene locus: BglI dimorphic site. Nucleic acids research 1987. PMID: 2881271


  185. Frossard PM, Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Funke H, Assmann G. DraI RFLP in the human apolipoprotein AI-CIII-AIV gene complex. Nucleic acids research 1986. PMID: 2878415


  186. Coleman RT, Dillan NA, Lim DW, Malloy MJ, Kane JP, Frossard PM. TaqI and XbaI RFLPs detected with a human apo IV (Apo4) cDNA probe. Nucleic acids research 1986. PMID: 2877436


  187. Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ. Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia. The Journal of clinical investigation 1986. PMID: 3745433


  188. Protter AA, Hardman DA, Sato KY, Schilling JW, Yamanaka M, Hort YJ, Hjerrild KA, Chen GC, Kane JP. Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B. Proceedings of the National Academy of Sciences of the United States of America 1986. PMID: 3461454


  189. Hardman DA, Gustafson A, Schilling JW, Donaldson VH, Kane JP. Scission of human apolipoprotein B-100 by kallikrein: characterization of the cleavage site. Biochemical and biophysical research communications 1986. PMID: 3637099


  190. Protter AA, Hardman DA, Schilling JW, Miller J, Appleby V, Chen GC, Kirsher SW, McEnroe G, Kane JP. Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B. Proceedings of the National Academy of Sciences of the United States of America 1986. PMID: 3513177


  191. Menzel HJ, Kane JP, Malloy MJ, Havel RJ. A variant primary structure of apolipoprotein C-II in individuals of African descent. The Journal of clinical investigation 1986. PMID: 3944271


  192. Mendel CM, Kunitake ST, Kane JP. Discrimination between subclasses of human high-density lipoproteins by the HDL binding sites of bovine liver. Biochimica et biophysica acta 1986. PMID: 3000454


  193. Kane JP. Speciation of HDL. Advances in experimental medicine and biology 1986. PMID: 3541521


  194. Kane JP, Havel RJ. Treatment of hypercholesterolemia. Annual review of medicine 1986. PMID: 3518611


  195. Kunitake ST, La Sala KJ, Kane JP. Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility. Journal of lipid research 1985. PMID: 3926924


  196. Chen GC, Guo LS, Hamilton RL, Gordon V, Richards EG, Kane JP. Circular dichroic spectra of apolipoprotein E in model complexes and cholesterol-rich lipoproteins: lipid contribution. Biochemistry 1984. PMID: 6529567


  198. McVicar JP, Kunitake ST, Hamilton RL, Kane JP. Characteristics of human lipoproteins isolated by selected-affinity immunosorption of apolipoprotein A-I. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6424116


  199. Stalenhoef AF, Malloy MJ, Kane JP, Havel RJ. Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6584917


  200. Phillips NR, Havel RJ, Kane JP. Sex-related differences in the concentrations of apolipoprotein E in human blood plasma and plasma lipoproteins. Journal of lipid research 1983. PMID: 6655368


  201. Hornick CA, Kita T, Hamilton RL, Kane JP, Havel RJ. Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits. Proceedings of the National Academy of Sciences of the United States of America 1983. PMID: 6577469


  202. Davis PA, Forte TM, Kane JP, Hardman DA, Krauss RM, Blum CB. Apolipoprotein and size heterogeneity in human umbilical cord blood low density lipoproteins. Biochimica et biophysica acta 1983. PMID: 6615856


  203. Havel RJ, Kotite L, Kane JP, Tun P, Bersot T. Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3. The Journal of clinical investigation 1983. PMID: 6860421


  204. Fielding PE, Fielding CJ, Havel RJ, Kane JP, Tun P. Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma. The Journal of clinical investigation 1983. PMID: 6826717


  205. Kane JP. Apolipoprotein B: structural and metabolic heterogeneity. Annual review of physiology 1983. PMID: 6342527


  206. Kane JP, Chen GC, Hamilton RL, Hardman DA, Malloy MJ, Havel RJ. Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia. Arteriosclerosis (Dallas, Tex.) 1983. PMID: 6824496


  207. Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS. Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia. Arteriosclerosis (Dallas, Tex.) 1982. PMID: 6960858


  208. Kunitake ST, Kane JP. Factors affecting the integrity of high density lipoproteins in the ultracentrifuge. Journal of lipid research 1982. PMID: 6813413


  209. Phillips NR, Havel RJ, Kane JP. Serum apolipoprotein A-I levels: relationship to lipoprotein lipid levels and selected demographic variables. American journal of epidemiology 1982. PMID: 6810694


  210. Guo LS, Hamilton RL, Kane JP, Fielding CJ, Chen GC. Characterization and quantitation of apolipoproteins A-I and E of normal and cholesterol-fed guinea pigs. Journal of lipid research 1982. PMID: 7182951


  211. Levy JA, Dimpfl J, Hardman D, Kane JP. Transfer of mouse anti-xenotropic virus neutralizing factor to human lipoproteins. Journal of virology 1982. PMID: 6283160


  212. Malloy MJ, Kane JP. Hypolipidemia. The Medical clinics of North America 1982. PMID: 7040848


  213. Kane JP, Malloy MJ. Treatment of hypercholesterolemia. The Medical clinics of North America 1982. PMID: 7040850


  214. Van't Hooft FM, Hardman DA, Kane JP, Havel RJ. Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America 1982. PMID: 6948299


  215. Havel RJ, Kane JP. Therapy of hyperlipidemic states. Annual review of medicine 1982. PMID: 7044276


  216. Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. The Journal of clinical investigation 1981. PMID: 6270194


  217. Malloy MJ, Kane JP, Hardman DA, Hamilton RL, Dalal KB. Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein. The Journal of clinical investigation 1981. PMID: 7229035


  218. Kane JP, Malloy MJ, Tun P, Phillips NR, Freedman DD, Williams ML, Rowe JS, Havel RJ. Normalization of low-density-lipoprotein levels in heterozygous familial hypercholesterolemia with a combined drug regimen. The New England journal of medicine 1981. PMID: 7003391


  220. Polz E, Kotite L, Havel RJ, Kane JP, Sata T. Human apolipoprotein C-I: concentration in blood serum and lipoproteins. Biochemical medicine 1980. PMID: 7283981


  221. Havel RJ, Kotite L, Vigne JL, Kane JP, Tun P, Phillips N, Chen GC. Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency. The Journal of clinical investigation 1980. PMID: 7440719


  222. Chen GC, Krieger M, Kane JP, Wu CS, Brown MS, Goldstein JL. beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism. Biochemistry 1980. PMID: 7426623


  223. Tan MH, Havel RJ, Gerich JE, Soeldner JS, Kane JP. Pancreatic alpha and beta cell function in familial dysbetalipoproteinemia. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 1980. PMID: 7000652


  224. Kane JP, Hardman DA, Paulus HE. Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons. Proceedings of the National Academy of Sciences of the United States of America 1980. PMID: 6930644


  225. Kane JP, Hardman DA, Dimpfl JC, Levy JA. Apolipoprotein is responsible for neutralization of xenotropic type C virus by mouse serum. Proceedings of the National Academy of Sciences of the United States of America 1979. PMID: 230495


  226. Chen GC, Kane JP. Secondary structure in very low density and intermediate density lipoproteins of human serum. Journal of lipid research 1979. PMID: 222856


  227. Havel RJ, Kotite L, Kane JP. Isoelectric heterogeneity of the cofactor protein for lipoprotein lipase in human blood plasma. Biochemical medicine 1979. PMID: 222259


  228. Abrams JJ, Grundy SM, Kane JP, Chang CM. Normocholesterolemic dysbetalipoproteinemia with xanthomatosis. Metabolism: clinical and experimental 1979. PMID: 216881


  229. Lie-Injo LE, Randhawa ZI, Kane JP, Ganesan J, George R. Heterogeneity of hemoglobin gamma chains in normal newborns and in cases of alpha and beta thalassemia. American journal of hematology 1979. PMID: 453194


  230. Kunitake ST, Loh E, Schumaker VN, Ma SK, Knobler CM, Kane JP, Hamilton RL. Molecular weight distributions of polydisperse systems: application to very low density lipoproteins. Biochemistry 1978. PMID: 207303


  231. Malloy MJ, Kane JP, Rowe JS. Familial hypercholesterolemia in children: treatment with p-aminosalicylic acid. Pediatrics 1978. PMID: 205828


  232. Kaufman JM, Fam B, Jacobs SC, Gabilondo F, Yalla S, Kane JP, Rossier AB. Bladder cancer and squamous metaplasia in spinal cord injury patients. The Journal of urology 1977. PMID: 926277


  234. Lie-Injo LE, Ganesan J, Randhawa ZI, Peterson D, Kane JP. Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia. American journal of hematology 1977. PMID: 602924


  235. Sata T, Havel RJ, Kotite L, Kane JP. New protein in human blood plasma, rich in proline, with lipid-binding properties. Proceedings of the National Academy of Sciences of the United States of America 1976. PMID: 1063389


  236. Wolfe BM, Havel JR, Marliss EB, Kane JP, Seymour J, Ahuja SP. Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men. The Journal of clinical investigation 1976. PMID: 176179


  237. Kane JP, Sata T, Hamilton RL, Havel RJ. Apoprotein composition of very low density lipoproteins of human serum. The Journal of clinical investigation 1975. PMID: 172534


  238. Faergeman O, Sata T, Kane JP, Havel RJ. Metabolism of apoprotein B of plasma very low density lipoproteins in the rat. The Journal of clinical investigation 1975. PMID: 172530


  239. Havel RJ, Kane JP. Quantification of triglyceride transport in blood plasma: a critical analysis. Federation proceedings 1975. PMID: 172371


  240. Chapman MJ, Kane JP. Stability of the apoprotein of human serum low density lipoprotein: absence of endogenous endopeptidase activity. Biochemical and biophysical research communications 1975. PMID: 170935


  241. Linscott WD, Kane JP. The complement system in cryoglobulinaemia. Interaction with immunoglobulins and lipoproteins. Clinical and experimental immunology 1975. PMID: 173488


  243. Kane JP, Malloy MJ. Editorial: Early prevention of atherosclerosis. The Western journal of medicine 1975. PMID: 1154774


  245. Wolfe BM, Kane JP, Havel RJ, Brewster HP. Mechanism of the hypolipemic effect of clofibrate in postabsorptive man. The Journal of clinical investigation 1973. PMID: 4353773


  246. Havel RJ, Kane JP. Primary dysbetalipoproteinemia: predominance of a specific apoprotein species in triglyceride-rich lipoproteins. Proceedings of the National Academy of Sciences of the United States of America 1973. PMID: 4352966


  248. Havel RJ, Kane JP. Drugs and lipid metabolism. Annual review of pharmacology 1973. PMID: 4576891


  249. Havel RJ, Kane JP, Kashyap ML. Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. The Journal of clinical investigation 1973. PMID: 4345202


  250. Hamilton RL, Havel RJ, Kane JP, Blaurock AE, Sata T. Cholestasis: lamellar structure of the abnormal human serum lipoprotein. Science (New York, N.Y.) 1971. PMID: 5550502


  251. Havel RJ, Kane JP, Balasse EO, Segel N, Basso LV. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. The Journal of clinical investigation 1970. PMID: 5475985


  252. Kane JP, Richards EG, Havel RJ. Subunit heterogeneity in human serum beta lipoprotein. Proceedings of the National Academy of Sciences of the United States of America 1970. PMID: 4990876


  253. Havel RJ, Balasse EO, Williams HE, Kane JP, Segel N. Splanchnic metabolism in von Gierke's disease (glycogenosis type I). Transactions of the Association of American Physicians 1969. PMID: 5375154


  254. KANE JP, LONGCOPE C, PAVLATOS FC, GRODSKY GM. STUDIES OF CARBOHYDRATE METABOLISM IN IDIOPATHIC HYPERTRIGLYCERIDEMIA. Metabolism: clinical and experimental 1965. PMID: 14288605


  255. KANE JP, FORSHAM PH. Sterol biosynthesis under the influence of a thyroxine analog (3,5-diiodothyroacetic acid). Metabolism: clinical and experimental 1962. PMID: 13962187